Thomas Roth Selected Research

Doxepin (Mareen)

2/2012	Efficacy and safety of doxepin 6 mg in a four-week outpatient trial of elderly adults with chronic primary insomnia.
10/2011	Efficacy and safety of doxepin 3 and 6 mg in a 35-day sleep laboratory trial in adults with chronic primary insomnia.
11/2010	Efficacy and Safety of Doxepin 1 mg and 3 mg in a 12-week Sleep Laboratory and Outpatient Trial of Elderly Subjects with Chronic Primary Insomnia.
10/2010	Efficacy and safety of doxepin 6 mg in a model of transient insomnia.
10/2008	Efficacy and safety of doxepin 1 mg, 3 mg, and 6 mg in elderly patients with primary insomnia: a randomized, double-blind, placebo-controlled crossover study.
11/2007	Efficacy and safety of doxepin 1 mg, 3 mg, and 6 mg in adults with primary insomnia.

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Thomas Roth Research Topics

Disease

112	Sleep Initiation and Maintenance Disorders (Insomnia) 03/2022 - 12/2000
37	Sleepiness 01/2022 - 10/2002
13	Disorders of Excessive Somnolence (Hypersomnia) 01/2020 - 08/2001
11	Narcolepsy 01/2022 - 04/2006
11	Pain (Aches) 01/2020 - 01/2004
11	Headache (Headaches) 12/2014 - 04/2006
9	Fatigue 01/2020 - 01/2002
9	Obstructive Sleep Apnea 10/2013 - 05/2003
7	Sleep Wake Disorders 01/2019 - 08/2001
7	Dizziness (Lightheadedness) 04/2012 - 02/2003
7	Nausea 07/2010 - 01/2006
5	Fibromyalgia (Fibrositis) 01/2020 - 04/2012
5	Neoplasms (Cancer) 01/2015 - 07/2002
4	Mental Disorders (Mental Disorder) 01/2019 - 01/2004
4	Cataplexy 01/2017 - 01/2007
4	Attention Deficit Disorder with Hyperactivity (Attention Deficit Hyperactivity Disorder) 10/2014 - 08/2009
4	Circadian Rhythm Sleep Disorders (Delayed Sleep Phase Syndrome) 07/2010 - 08/2005
4	Apnea 03/2009 - 08/2001
3	Weight Gain 01/2020 - 11/2010
3	Restless Legs Syndrome (Restless Legs) 01/2016 - 02/2009
3	Substance-Related Disorders (Drug Abuse) 07/2012 - 02/2004
3	Major Depressive Disorder (Major Depressive Disorders) 07/2011 - 06/2006
3	Chronic Obstructive Pulmonary Disease (COPD) 03/2009 - 08/2008
2	Infections 03/2021 - 10/2007
2	Acquired Immunodeficiency Syndrome (AIDS) 01/2017 - 02/2004
2	Sleep Deprivation 10/2014 - 04/2008
2	Neuralgia (Stump Neuralgia) 06/2014 - 10/2010
2	Alcoholism (Alcohol Abuse) 02/2011 - 01/2009
2	Migraine Disorders (Migraine) 10/2010 - 05/2006
2	Anxiety Disorders (Anxiety Disorder) 06/2009 - 05/2008
2	Carcinoma (Carcinomatosis) 12/2007 - 06/2006
2	Sleep Apnea Syndromes (Sleep Apnea) 09/2007 - 08/2001
2	Mood Disorders (Mood Disorder) 02/2007 - 05/2006
1	Death (Near-Death Experience) 01/2022
1	Right Ventricular Dysfunction 01/2021
1	Substance Withdrawal Syndrome (Withdrawal Symptoms) 01/2020
1	Nocturia 01/2019
1	Panic Disorder (Panic Attack) 08/2018

Drug/Important Bio-Agent (IBA)

21	Hypnotics and Sedatives (Sedatives)IBA 01/2020 - 03/2001
18	Pharmaceutical PreparationsIBA 01/2020 - 01/2002
17	Zolpidem (Ambien)FDA LinkGeneric 01/2019 - 03/2001
15	Modafinil (Provigil)FDA Link 12/2017 - 08/2005
12	Orexin Receptor AntagonistsIBA 01/2022 - 12/2012
12	suvorexantIBA 01/2020 - 12/2012
12	Eszopiclone (Lunesta)FDA Link 02/2010 - 11/2003
11	ramelteon (Rozerem)FDA Link 10/2011 - 03/2005
7	Sodium Oxybate (gamma Hydroxybutyrate)FDA Link 01/2022 - 01/2007
7	BenzodiazepinesIBA 08/2018 - 12/2004
6	Antidepressive Agents (Antidepressants)IBA 10/2016 - 02/2004
6	Doxepin (Mareen)FDA LinkGeneric 02/2012 - 11/2007
6	Melatonin Receptors (Melatonin Receptor)IBA 10/2011 - 07/2007
5	MelatoninIBA 01/2018 - 05/2007
5	Caffeine (No Doz)FDA LinkGeneric 04/2012 - 02/2003
4	OrexinsIBA 11/2020 - 07/2013
4	Mirtazapine (Rexer)FDA LinkGeneric 01/2020 - 07/2015
4	Pregabalin (Lyrica)FDA Link 04/2016 - 10/2010
4	Pain-FreeIBA 04/2016 - 03/2005
4	Lisdexamfetamine Dimesylate FDA Link 12/2014 - 08/2009
4	Ethanol (Ethyl Alcohol)IBA 08/2004 - 08/2001
3	Diphenhydramine (Benadryl)FDA LinkGeneric 11/2019 - 10/2002
3	Hydrocortisone (Cortisol)FDA LinkGeneric 01/2019 - 02/2007
3	Biological ProductsIBA 10/2017 - 03/2005
3	GABA-A Receptors (GABA(A) Receptor)IBA 02/2017 - 03/2003
3	Analgesics (Analgesic Drugs)IBA 01/2017 - 06/2010
3	dimemorfan (AT 17)IBA 06/2015 - 05/2007
3	Escitalopram FDA Link 07/2011 - 05/2008
3	zaleplon (Sonata)FDA LinkGeneric 01/2009 - 12/2000
3	indiplonIBA 12/2007 - 06/2007
3	MT2 Melatonin ReceptorIBA 08/2007 - 03/2005
3	Tiagabine (Gabitril)FDA Link 03/2006 - 01/2006
2	gaboxadol (THIP)IBA 01/2020 - 02/2010
2	Indicators and Reagents (Reagents)IBA 01/2019 - 07/2006
2	SaltsIBA 10/2016 - 07/2011
2	Polymethyl Methacrylate (Sol)IBA 10/2016 - 01/2015
2	Orexin ReceptorsIBA 01/2016 - 12/2012
2	Serotonin (5 Hydroxytryptamine)IBA 07/2015 - 12/2008
2	CatecholaminesIBA 03/2015 - 07/2007
2	Gabapentin (Neurontin)FDA LinkGeneric 10/2014 - 10/2014
2	Methylphenidate (Ritalin)FDA LinkGeneric 10/2014 - 08/2004
2	N-(4-aminophenethyl)spiroperidol (NAPS)IBA 06/2014 - 07/2003
2	Histamine (Histamine Dihydrochloride)FDA Link 08/2013 - 02/2012
2	TabletsIBA 02/2013 - 10/2010
2	Nicotine FDA Link 07/2012 - 01/2009
2	Cholinergic Antagonists (Anticholinergics)IBA 10/2011 - 11/2010
2	Trazodone (Trittico)FDA LinkGeneric 01/2009 - 02/2004
2	Hormones (Hormone)IBA 11/2007 - 02/2007
2	Fluoxetine (Prozac)FDA LinkGeneric 02/2007 - 06/2006
2	Triazolam (Halcion)FDA LinkGeneric 01/2002 - 12/2000
1	daridorexantIBA 01/2022
1	lemborexantIBA 01/2022
1	Anti-Bacterial Agents (Antibiotics)IBA 03/2021
1	Biomarkers (Surrogate Marker)IBA 01/2021
1	almorexantIBA 02/2017
1	AnticoagulantsIBA 01/2017

Therapy/Procedure

18	Therapeutics 03/2022 - 07/2002
6	Continuous Positive Airway Pressure 10/2013 - 05/2003
6	Drug Therapy (Chemotherapy) 10/2012 - 01/2007
4	Aftercare (After-Treatment) 01/2019 - 10/2014
1	Critical Care (Surgical Intensive Care) 03/2021
1	Oral Administration 02/2017